These symptoms frequently lead to a greater difficulty in performing activities of daily living (ADL) and this impacts negatively on quality of life (QOL). While ET was classically considered a monosymptomatic tremor disorder, non-motor clinical symptoms, including cognitive and mood issues, are now increasingly recognized as important features of the disease. Tremors of the voice, legs, or trunk are less common. The core clinical symptoms of ET are postural and action/intentional tremor of the arms and head. The following authors declared that no competing interests exist: MH, DMR, DT, BA, HM, SC, CWH, DB, HEW, LRW, MMD, MST, SJK, and EH.Įssential tremor (ET) is one of the most common movement disorders with a reported prevalence varying from 0.4% to 3.9% in population-based studies, and has an incidence which increases with age. Okun has participated as a site PI and/or co-I for several NIH, foundation, and industry sponsored trials over the years but has not received honoraria. Jude, and the PI has no financial interest in these grants. Okun receives grants from Medtronic and ANS/St. Okun has participated in CME activities on movement disorders (in the last 36) months sponsored by PeerView, Prime, and by Vanderbilt University. Okun is an associate editor for New England Journal of Medicine Journal Watch Neurology. Okun has received royalties for publications with Demos, Manson, Amazon, Smashwords, and Cambridge (movement disorders books). Okun has previously received honoraria, but in the past >60 months has received no support from industry. Fox Foundation, the Parkinson Alliance, Smallwood Foundation, the Bachmann-Strauss Foundation, the Tourette Syndrome Association, and the UF Foundation. MSO serves as a consultant for the National Parkinson Foundation, and has received research grants from NIH, NPF, the Michael J. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: The authors have no support or funding to report.Ĭompeting interests: The authors of this manuscript have the following competing interests: KDF receives grant support from NIH, NPF and University of Florida Foundation. Received: OctoAccepted: DecemPublished: December 28, 2015Ĭopyright: © 2015 Higuchi et al. PLoS ONE 10(12):Įditor: Pedro Gonzalez-Alegre, University of Pennsylvania Perelman School of Medicine, UNITED STATES (2015) Impact of an Interdisciplinary Deep Brain Stimulation Screening Model on Post-Surgical Complications in Essential Tremor Patients. Citation: Higuchi M-a, Topiol DD, Ahmed B, Morita H, Carbunaru S, Hess CW, et al.